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- Bdd4e490d086852f0ed82008677fb0808 NCIT_P378 "NCI" @default.
- Bdd4e490d086852f0ed82008677fb0808 type Axiom @default.
- Bdd4e490d086852f0ed82008677fb0808 annotatedProperty IAO_0000115 @default.
- Bdd4e490d086852f0ed82008677fb0808 annotatedSource NCIT_C368 @default.
- Bdd4e490d086852f0ed82008677fb0808 annotatedTarget "Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)" @default.