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- Bdd80f662534f56fe8d403c77779f3833 NCIT_P378 "NCI" @default.
- Bdd80f662534f56fe8d403c77779f3833 type Axiom @default.
- Bdd80f662534f56fe8d403c77779f3833 annotatedProperty IAO_0000115 @default.
- Bdd80f662534f56fe8d403c77779f3833 annotatedSource NCIT_C123765 @default.
- Bdd80f662534f56fe8d403c77779f3833 annotatedTarget "Epidermal growth factor receptor protein (EGFR) bearing phosphorylated tyrosine residues within the 194 amino acids of the carboxyl-terminal intracellular domain of the protein. Five ligand-dependent autophosphorylation sites have been identified; overexpression or mutation of EGFR can decouple ligand-binding from autophosphorylation and the subsequent activation of downstream signaling pathways. The presence of phosphorylated EGFR in a malignant tumor is generally correlated with poor prognosis and could be used as a predictive biomarker to identify individuals who may respond to EGFR-tyrosine kinase inhibitor treatment." @default.