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- Bdd9b6f0466b731673af75261c6238208 NCIT_P378 "NCI" @default.
- Bdd9b6f0466b731673af75261c6238208 type Axiom @default.
- Bdd9b6f0466b731673af75261c6238208 annotatedProperty IAO_0000115 @default.
- Bdd9b6f0466b731673af75261c6238208 annotatedSource NCIT_C157039 @default.
- Bdd9b6f0466b731673af75261c6238208 annotatedTarget "An orally available, small-molecule, allosteric activator of the red cell isoform of pyruvate kinase (PK-R), with potential to improve hemolytic anemia in patients with pyruvate kinase deficiency (PKD). Upon oral administration, mitapivat binds to and activates PK-R, thereby enhancing glycolytic pathway activity, improving adenosine triphosphate (ATP) levels and reducing 2,3-diphosphoglycerate (2,3-DPG) levels. Mutations in PK-R cause deficiency in PK-R which prevents adequate red blood cell (RBC) glycolysis, leading to a buildup of the upstream glycolytic intermediate 2,3-DPG and deficiency in the PK-R product ATP." @default.