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- Bdda4dbf6b0391a14ceed8162431d4aba NCIT_P378 "NCI" @default.
- Bdda4dbf6b0391a14ceed8162431d4aba type Axiom @default.
- Bdda4dbf6b0391a14ceed8162431d4aba annotatedProperty IAO_0000115 @default.
- Bdda4dbf6b0391a14ceed8162431d4aba annotatedSource NCIT_C79845 @default.
- Bdda4dbf6b0391a14ceed8162431d4aba annotatedTarget "A replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector expressing the human preproenkephalin A (PPE) gene with potential antinociceptive activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1 vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion (DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with high efficiency, delivering the engineered PPE gene; transduced neurons then express the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met- and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the inhibition of nociceptive neurotransmission." @default.