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- Bddbc33e1fb3e581c4029cf878e5599f2 NCIT_P378 "NCI" @default.
- Bddbc33e1fb3e581c4029cf878e5599f2 type Axiom @default.
- Bddbc33e1fb3e581c4029cf878e5599f2 annotatedProperty IAO_0000115 @default.
- Bddbc33e1fb3e581c4029cf878e5599f2 annotatedSource NCIT_C49084 @default.
- Bddbc33e1fb3e581c4029cf878e5599f2 annotatedTarget "A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase (hTR) RNA, imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a telomerase template antagonist), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis." @default.