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- Bddc5d83659016b8d4ea4d3ff275cd12c NCIT_P378 "NCI" @default.
- Bddc5d83659016b8d4ea4d3ff275cd12c type Axiom @default.
- Bddc5d83659016b8d4ea4d3ff275cd12c annotatedProperty IAO_0000115 @default.
- Bddc5d83659016b8d4ea4d3ff275cd12c annotatedSource NCIT_C70983 @default.
- Bddc5d83659016b8d4ea4d3ff275cd12c annotatedTarget "An orally bioavailable small molecule multi-kinase inhibitor with antineoplastic activity. Aurora kinase/VEGFR 2 inhibitor CYC116 inhibits Aurora kinases A and B and vascular endothelial growth factor receptor 2 (VEGFR2), resulting in disruption of the cell cycle, rapid cell death, and the inhibition of angiogenesis. Aurora kinases are serine/threonine protein kinases that are only expressed in actively dividing cells and are critical in division or mitosis. VEGFR2 is a receptor tyrosine kinase that appears to account for most of the mitogenic and chemotactic effects of vascular endothelial growth factor (VEGF) on adult endothelial cells." @default.