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- Bddce6ac8f81bb4c49ef4fd1927db03c8 NCIT_P378 "NCI" @default.
- Bddce6ac8f81bb4c49ef4fd1927db03c8 type Axiom @default.
- Bddce6ac8f81bb4c49ef4fd1927db03c8 annotatedProperty IAO_0000115 @default.
- Bddce6ac8f81bb4c49ef4fd1927db03c8 annotatedSource NCIT_C1379 @default.
- Bddce6ac8f81bb4c49ef4fd1927db03c8 annotatedTarget "A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. (NCI04)" @default.