Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bde1ac16c2a697c539db8c29b2049e258> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bde1ac16c2a697c539db8c29b2049e258 NCIT_P378 "NCI" @default.
- Bde1ac16c2a697c539db8c29b2049e258 type Axiom @default.
- Bde1ac16c2a697c539db8c29b2049e258 annotatedProperty IAO_0000115 @default.
- Bde1ac16c2a697c539db8c29b2049e258 annotatedSource NCIT_C1395 @default.
- Bde1ac16c2a697c539db8c29b2049e258 annotatedTarget "The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. (NCI04)" @default.