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- Bdec5e5d75cc6035dee1b93438eba61bd NCIT_P378 "NCI" @default.
- Bdec5e5d75cc6035dee1b93438eba61bd type Axiom @default.
- Bdec5e5d75cc6035dee1b93438eba61bd annotatedProperty IAO_0000115 @default.
- Bdec5e5d75cc6035dee1b93438eba61bd annotatedSource NCIT_C184310 @default.
- Bdec5e5d75cc6035dee1b93438eba61bd annotatedTarget "A radioconjugate containing PT2385, a small molecule inhibitor of the hypoxia inducible factor (HIF)-2alpha, conjugated to the positron-emitting isotope fluorine F 18, with potential imaging activity upon positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18 PT2385, the PT2385 moiety specifically targets and binds to HIF-2alpha overexpressed on tumor cells, thereby allowing the visualization of tumor cells expressing HIF-2alpha upon PET/CT. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors." @default.