Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bdec7f18e0b8c11e3d8c85db28bb32dff> ?p ?o ?g. }
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- Bdec7f18e0b8c11e3d8c85db28bb32dff NCIT_P378 "NCI" @default.
- Bdec7f18e0b8c11e3d8c85db28bb32dff type Axiom @default.
- Bdec7f18e0b8c11e3d8c85db28bb32dff annotatedProperty IAO_0000115 @default.
- Bdec7f18e0b8c11e3d8c85db28bb32dff annotatedSource NCIT_C124229 @default.
- Bdec7f18e0b8c11e3d8c85db28bb32dff annotatedTarget "A bifunctional fusion protein composed of an anti-programmed death ligand 1 (PD-L1) human monoclonal antibody, bound to the soluble extracellular domain of human transforming growth factor beta (TGFbeta) receptor type II (TGFbetaRII), with potential antineoplastic and immune checkpoint modulating activities. Upon administration, bintrafusp alfa binds to and neutralizes activated TGFbeta and binds to PD-L1. This prevents TGFbeta- and PD-L1-mediated signaling, and increases natural killer (NK) cell and cytotoxic T-lymphocyte (CTL) activities. This inhibits tumor cell proliferation in susceptible tumor cells. TGFbeta and PD-L1 are both upregulated in certain types of cancers; their overexpression is associated with increased evasion of immune surveillance and contributes to poor prognosis." @default.