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- Be02e3eb7b5a850a19d9292a1ae375395 NCIT_P378 "NCI" @default.
- Be02e3eb7b5a850a19d9292a1ae375395 type Axiom @default.
- Be02e3eb7b5a850a19d9292a1ae375395 annotatedProperty IAO_0000115 @default.
- Be02e3eb7b5a850a19d9292a1ae375395 annotatedSource NCIT_C176568 @default.
- Be02e3eb7b5a850a19d9292a1ae375395 annotatedTarget "A preparation of autologous human T-lymphocytes that are genetically engineered to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD22, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous anti-CD22 CAR-expressing T-cells SCRI-CAR22v2 express anti-CD22-CAR on their cell surfaces and bind to the CD22 antigen on tumor cell surfaces leading to lysis of CD22-expressing B-cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells." @default.