Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Be07c283c3b4bf6813c7e342c29b9abf4> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Be07c283c3b4bf6813c7e342c29b9abf4 NCIT_P378 "NCI" @default.
- Be07c283c3b4bf6813c7e342c29b9abf4 type Axiom @default.
- Be07c283c3b4bf6813c7e342c29b9abf4 annotatedProperty IAO_0000115 @default.
- Be07c283c3b4bf6813c7e342c29b9abf4 annotatedSource NCIT_C133717 @default.
- Be07c283c3b4bf6813c7e342c29b9abf4 annotatedTarget "A poly (ADP-ribose) polymerase type 1 (PARP1) fluorescence imaging agent based on the PARP1 inhibitor olaparib, in which the cyclopropane group of olaparib is replaced by the green fluorescent dye boron-dipyrromethene (BODIPY) fluorophore (FL), with potential fluorescent imaging activity. Upon administration of the fluorescent PARP1 inhibitor PARPi-FL, the olaparib binding moiety specifically targets and binds to PARP1, which is often overexpressed on cancer cells. Upon fluorescent imaging, the PARP1-expressing cancer cells can be visualized. PARP1, the nuclear enzyme that catalyzes post-translational ADP-ribosylation of nuclear proteins, is activated by single-strand (SS) DNA breaks and overexpressed in certain tumor cells; it plays a key role in DNA repair, tumor cell resistance and survival." @default.