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- Be0a802cc6e3ce558913dce9b789a5a73 NCIT_P378 "NCI" @default.
- Be0a802cc6e3ce558913dce9b789a5a73 type Axiom @default.
- Be0a802cc6e3ce558913dce9b789a5a73 annotatedProperty IAO_0000115 @default.
- Be0a802cc6e3ce558913dce9b789a5a73 annotatedSource NCIT_C88303 @default.
- Be0a802cc6e3ce558913dce9b789a5a73 annotatedTarget "A small-molecule receptor tyrosine kinase (RTK) inhibitor of proto-oncogene receptor tyrosine kinase (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), with antineoplastic activity. Upon oral administration, pexidartinib targets, binds to and inhibits phosphorylation of KIT, CSF1R and FLT3 harboring an internal tandem duplication (ITD) mutation. This results in the inhibition of tumor cell proliferation. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis." @default.