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- Be0de3086acb2f0a4b6fe155716ba61ce NCIT_P378 "NCI" @default.
- Be0de3086acb2f0a4b6fe155716ba61ce type Axiom @default.
- Be0de3086acb2f0a4b6fe155716ba61ce annotatedProperty IAO_0000115 @default.
- Be0de3086acb2f0a4b6fe155716ba61ce annotatedSource NCIT_C121543 @default.
- Be0de3086acb2f0a4b6fe155716ba61ce annotatedTarget "An orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication." @default.