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- Be15f89e965b2b9f3edbd0b9b7d5986f0 NCIT_P378 "NCI" @default.
- Be15f89e965b2b9f3edbd0b9b7d5986f0 type Axiom @default.
- Be15f89e965b2b9f3edbd0b9b7d5986f0 annotatedProperty IAO_0000115 @default.
- Be15f89e965b2b9f3edbd0b9b7d5986f0 annotatedSource NCIT_C114384 @default.
- Be15f89e965b2b9f3edbd0b9b7d5986f0 annotatedTarget "An orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein family, including Bcl-2, Bcl-xl and Bcl-w. This inhibits the activity of these pro-survival proteins and restores apoptotic processes in tumor cells, via activation of Bak/Bax-mediated apoptosis. The pro-survival Bcl-2 proteins are overexpressed in many cancers and play important roles in the regulation of apoptosis. Their expression is associated with increased drug resistance and tumor cell survival. ABT-737 does not inhibit the pro-survival proteins Mcl-1, Bcl-B, Bfl-1 (A1); therefore, tumors that overexpress these Bcl-2 family proteins are resistant to ABT-737." @default.