Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Be1635c643e014121b86a3ba5c5031665> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Be1635c643e014121b86a3ba5c5031665 NCIT_P378 "NCI" @default.
- Be1635c643e014121b86a3ba5c5031665 type Axiom @default.
- Be1635c643e014121b86a3ba5c5031665 annotatedProperty IAO_0000115 @default.
- Be1635c643e014121b86a3ba5c5031665 annotatedSource NCIT_C2571 @default.
- Be1635c643e014121b86a3ba5c5031665 annotatedTarget "An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis." @default.