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- Be25a2300530911139c6249d3085e5e42 NCIT_P378 "NCI" @default.
- Be25a2300530911139c6249d3085e5e42 type Axiom @default.
- Be25a2300530911139c6249d3085e5e42 annotatedProperty IAO_0000115 @default.
- Be25a2300530911139c6249d3085e5e42 annotatedSource NCIT_C91409 @default.
- Be25a2300530911139c6249d3085e5e42 annotatedTarget "The hydrochloride salt of a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation." @default.