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- Be28126295c75d56cf429a58963f6c82d NCIT_P378 "NCI" @default.
- Be28126295c75d56cf429a58963f6c82d type Axiom @default.
- Be28126295c75d56cf429a58963f6c82d annotatedProperty IAO_0000115 @default.
- Be28126295c75d56cf429a58963f6c82d annotatedSource NCIT_C288 @default.
- Be28126295c75d56cf429a58963f6c82d annotatedTarget "A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation. Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)" @default.