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- Be283568781382f49ee1d69645c2f7011 NCIT_P378 "NCI" @default.
- Be283568781382f49ee1d69645c2f7011 type Axiom @default.
- Be283568781382f49ee1d69645c2f7011 annotatedProperty IAO_0000115 @default.
- Be283568781382f49ee1d69645c2f7011 annotatedSource NCIT_C945 @default.
- Be283568781382f49ee1d69645c2f7011 annotatedTarget "A synthetic anticoagulant. Warfarin inhibits the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity." @default.