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- Be2b87f1b8d9c5a221ed7a1f770c6fe1e NCIT_P378 "NCI" @default.
- Be2b87f1b8d9c5a221ed7a1f770c6fe1e type Axiom @default.
- Be2b87f1b8d9c5a221ed7a1f770c6fe1e annotatedProperty IAO_0000115 @default.
- Be2b87f1b8d9c5a221ed7a1f770c6fe1e annotatedSource NCIT_C180828 @default.
- Be2b87f1b8d9c5a221ed7a1f770c6fe1e annotatedTarget "A monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin18.2 (CLDN18.2; A2 isoform of claudin-18), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN18.2 monoclonal antibody M108 specifically targets, binds to and inhibits CLDN18.2 expressed on tumor cells. The binding induces antibody-dependent cellular cytotoxicity (ADCC) and may kill CLDN18.2-expressing tumor cells and inhibit cell proliferation. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.