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- Be2c2077684f9df03c9f51996ac122fda NCIT_P378 "NCI" @default.
- Be2c2077684f9df03c9f51996ac122fda type Axiom @default.
- Be2c2077684f9df03c9f51996ac122fda annotatedProperty IAO_0000115 @default.
- Be2c2077684f9df03c9f51996ac122fda annotatedSource NCIT_C65337 @default.
- Be2c2077684f9df03c9f51996ac122fda annotatedTarget "An orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors." @default.