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- Be3f03e994ed804c477163bcfc5f12d6a NCIT_P378 "NCI" @default.
- Be3f03e994ed804c477163bcfc5f12d6a type Axiom @default.
- Be3f03e994ed804c477163bcfc5f12d6a annotatedProperty IAO_0000115 @default.
- Be3f03e994ed804c477163bcfc5f12d6a annotatedSource NCIT_C78058 @default.
- Be3f03e994ed804c477163bcfc5f12d6a annotatedTarget "The sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids." @default.