Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Be48511aa1e67ce8240739adb3f7f6b4b> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Be48511aa1e67ce8240739adb3f7f6b4b NCIT_P378 "NCI" @default.
- Be48511aa1e67ce8240739adb3f7f6b4b type Axiom @default.
- Be48511aa1e67ce8240739adb3f7f6b4b annotatedProperty IAO_0000115 @default.
- Be48511aa1e67ce8240739adb3f7f6b4b annotatedSource NCIT_C64543 @default.
- Be48511aa1e67ce8240739adb3f7f6b4b annotatedTarget "A water-soluble triazole prodrug with broad-spectrum antifungal activity. Isavuconazole is absorbed easily, given either orally or intravenously, and is hydrolyzed to its active moiety BAL4815 by plasma esterases. BAL4815 inhibits fungal cytochrome P450 lanosterol 14-alpha-demethylase (CYP51) that catalyzes the conversion of lanosterol to ergosterol, an important component of the fungal cell membrane. Enzyme inhibition by this agent leads to a decrease in ergosterol pool and therefore disturbs synthesis of fungal cell membrane, thereby increasing cell membrane permeability and promoting loss of essential intracellular elements. This ultimately causes fungal cell lysis and death." @default.