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- Be50c7572c8f982f20bcf361ee0ad5338 NCIT_P378 "NCI" @default.
- Be50c7572c8f982f20bcf361ee0ad5338 type Axiom @default.
- Be50c7572c8f982f20bcf361ee0ad5338 annotatedProperty IAO_0000115 @default.
- Be50c7572c8f982f20bcf361ee0ad5338 annotatedSource NCIT_C78825 @default.
- Be50c7572c8f982f20bcf361ee0ad5338 annotatedTarget "An orally bioavailable, small molecule inhibitor of the delta isoform of the 110 kDa catalytic subunit of class I phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Idelalisib inhibits the production of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), preventing the activation of the PI3K signaling pathway and inhibiting tumor cell proliferation, motility, and survival. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells." @default.