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- Be54eb9c4f9c85203811f0aa57f3f5acd NCIT_P378 "NCI" @default.
- Be54eb9c4f9c85203811f0aa57f3f5acd type Axiom @default.
- Be54eb9c4f9c85203811f0aa57f3f5acd annotatedProperty IAO_0000115 @default.
- Be54eb9c4f9c85203811f0aa57f3f5acd annotatedSource NCIT_C162807 @default.
- Be54eb9c4f9c85203811f0aa57f3f5acd annotatedTarget "An antisense oligonucleotide targeting the growth hormone receptor (GHR; somatotropin receptor) mRNA, with potential somatotropin-inhibiting activity. Upon subcutaneous administration, cimdelirsen hybridizes with GHR mRNA, which blocks translation of the GHR protein. Reduction of GHR levels in turn decreases the circulating level of insulin-like growth factor-1 (IGF-1). IGF-1 is a hormone that plays an important role in childhood growth and has anabolic effects in adults. Excess production of IGF-1 results in various disease states including acromegaly." @default.