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- Be56992d48ec09e7e9c7218384ad62406 NCIT_P378 "NCI" @default.
- Be56992d48ec09e7e9c7218384ad62406 type Axiom @default.
- Be56992d48ec09e7e9c7218384ad62406 annotatedProperty IAO_0000115 @default.
- Be56992d48ec09e7e9c7218384ad62406 annotatedSource NCIT_C61614 @default.
- Be56992d48ec09e7e9c7218384ad62406 annotatedTarget "A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS), which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis." @default.