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- Be57c958fa16e2b7ac49cf433e82babc3 NCIT_P378 "NCI" @default.
- Be57c958fa16e2b7ac49cf433e82babc3 type Axiom @default.
- Be57c958fa16e2b7ac49cf433e82babc3 annotatedProperty IAO_0000115 @default.
- Be57c958fa16e2b7ac49cf433e82babc3 annotatedSource NCIT_C958 @default.
- Be57c958fa16e2b7ac49cf433e82babc3 annotatedTarget "A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04)" @default.