Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Be5a6f8307eac110038eca5b33953edac> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Be5a6f8307eac110038eca5b33953edac NCIT_P378 "NCI" @default.
- Be5a6f8307eac110038eca5b33953edac type Axiom @default.
- Be5a6f8307eac110038eca5b33953edac annotatedProperty IAO_0000115 @default.
- Be5a6f8307eac110038eca5b33953edac annotatedSource NCIT_C506 @default.
- Be5a6f8307eac110038eca5b33953edac annotatedTarget "A diphenhydramine derivative and selective serotonin reuptake inhibitor with antidepressant, anti-anxiety, antiobsessional and antibulimic activity and with potential immunomodulating activity. Upon administration, fluoxetine binds to the presynaptic serotonin (5-HT) receptor resulting in negative allosteric modulation of the receptor complex, thereby blocking recycling of serotonin by the presynaptic receptor. Inhibition of serotonin reuptake by fluoxetine enhances serotonergic function through serotonin accumulation in the synaptic space, resulting in long-term desensitization and downregulation of 5-HT receptors, preventing 5-HT-mediated signaling and leading to antidepressant, anti-anxiety, antiobsessional and antibulimic effects. In addition, fluoxetine may inhibit the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6). This may prevent IL-6-mediated inflammation and cytokine storm." @default.