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- Be5e9da93e8f48cfaa44cfcb27798e845 NCIT_P378 "NCI" @default.
- Be5e9da93e8f48cfaa44cfcb27798e845 type Axiom @default.
- Be5e9da93e8f48cfaa44cfcb27798e845 annotatedProperty IAO_0000115 @default.
- Be5e9da93e8f48cfaa44cfcb27798e845 annotatedSource NCIT_C14099 @default.
- Be5e9da93e8f48cfaa44cfcb27798e845 annotatedTarget "In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)" @default.