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- Be6040f292e664e5de19f7c8dba69ef80 NCIT_P378 "NCI" @default.
- Be6040f292e664e5de19f7c8dba69ef80 type Axiom @default.
- Be6040f292e664e5de19f7c8dba69ef80 annotatedProperty IAO_0000115 @default.
- Be6040f292e664e5de19f7c8dba69ef80 annotatedSource NCIT_C200057 @default.
- Be6040f292e664e5de19f7c8dba69ef80 annotatedTarget "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody targeting folate receptor alpha (FRa; FolRa; FOLR1) conjugated to a camptothecin-based topoisomerase 1 inhibitor AZ14170132, with potential antineoplastic activity. Upon administration of anti-FRa ADC AZD5335, the antibody moiety targets and binds to FRa expressed on tumor cells. Upon binding, cellular uptake and linker cleavage, AZ14170132 is released. AZ14170132 inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and generating DNA single- and double-strand breaks, and leading to cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of FRa-expressing tumor cells. FRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers while its expression is limited in normal tissues." @default.