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- Be613478d801d921c5562cfefab556a69 NCIT_P378 "NCI" @default.
- Be613478d801d921c5562cfefab556a69 type Axiom @default.
- Be613478d801d921c5562cfefab556a69 annotatedProperty IAO_0000115 @default.
- Be613478d801d921c5562cfefab556a69 annotatedSource NCIT_C62034 @default.
- Be613478d801d921c5562cfefab556a69 annotatedTarget "The hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons." @default.