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- Be6d1ccd4068a056dee34b6cbeef004f6 NCIT_P378 "NCI" @default.
- Be6d1ccd4068a056dee34b6cbeef004f6 type Axiom @default.
- Be6d1ccd4068a056dee34b6cbeef004f6 annotatedProperty IAO_0000115 @default.
- Be6d1ccd4068a056dee34b6cbeef004f6 annotatedSource NCIT_C47753 @default.
- Be6d1ccd4068a056dee34b6cbeef004f6 annotatedTarget "The hydrochloride salt form of thiothixene, a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors." @default.