Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Be6e192acde9257113066abbac57b3528> ?p ?o ?g. }
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- Be6e192acde9257113066abbac57b3528 NCIT_P378 "NCI" @default.
- Be6e192acde9257113066abbac57b3528 type Axiom @default.
- Be6e192acde9257113066abbac57b3528 annotatedProperty IAO_0000115 @default.
- Be6e192acde9257113066abbac57b3528 annotatedSource NCIT_C1212 @default.
- Be6e192acde9257113066abbac57b3528 annotatedTarget "A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with immunosuppressant properties. In cells, sirolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase. This results in inhibition of T lymphocyte activation and proliferation that occurs in response to antigenic and cytokine (IL-2, IL-4, and IL-15) stimulation and inhibition of antibody production. (NCI04)" @default.