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- Be76e6d8a0c7456a9eb1057ad46f7153c NCIT_P378 "NCI" @default.
- Be76e6d8a0c7456a9eb1057ad46f7153c type Axiom @default.
- Be76e6d8a0c7456a9eb1057ad46f7153c annotatedProperty IAO_0000115 @default.
- Be76e6d8a0c7456a9eb1057ad46f7153c annotatedSource NCIT_C82623 @default.
- Be76e6d8a0c7456a9eb1057ad46f7153c annotatedTarget "An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity." @default.