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- Be78ae81c9ab298215f1f1f7d5c2788b0 NCIT_P378 "NCI" @default.
- Be78ae81c9ab298215f1f1f7d5c2788b0 type Axiom @default.
- Be78ae81c9ab298215f1f1f7d5c2788b0 annotatedProperty IAO_0000115 @default.
- Be78ae81c9ab298215f1f1f7d5c2788b0 annotatedSource NCIT_C90585 @default.
- Be78ae81c9ab298215f1f1f7d5c2788b0 annotatedTarget "An orally bioavailable, highly selective small molecule inhibitor of the serine/threonine protein kinase Aurora A, with potential antimitotic and antineoplastic activity. Aurora A kinase inhibitor MK5108 binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and eventually inhibition of cell division, proliferation and an induction of apoptosis in cells overexpressing Aurora A kinase. Aurora A kinase localizes to the spindle poles and to spindle microtubules during mitosis, and is thought to regulate spindle assembly. Aurora kinases are overexpressed in a wide variety of cancers." @default.