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- Be79cc270da79263e0aa1244ee6c3d7e1 NCIT_P378 "NCI" @default.
- Be79cc270da79263e0aa1244ee6c3d7e1 type Axiom @default.
- Be79cc270da79263e0aa1244ee6c3d7e1 annotatedProperty IAO_0000115 @default.
- Be79cc270da79263e0aa1244ee6c3d7e1 annotatedSource NCIT_C82922 @default.
- Be79cc270da79263e0aa1244ee6c3d7e1 annotatedTarget "Any synthetic or semi-synthetic derivative of lincomycin, first isolated from a soil actinomycete Streptomyces lincolnensis, with antibacterial activity. Lincosamide antibiotics bind to the 23S rRNA in the large 50S subunit of bacterial ribosomes, thereby preventing the peptidyl-tRNA translocation from the A site to the P site. This results in peptidyl-tRNA dissociation from ribosomes, and leads to the release of incomplete proteins, ultimately causing cell death." @default.