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- Be83d975d5d1c23646df66c223c2379fe NCIT_P378 "NCI" @default.
- Be83d975d5d1c23646df66c223c2379fe type Axiom @default.
- Be83d975d5d1c23646df66c223c2379fe annotatedProperty IAO_0000115 @default.
- Be83d975d5d1c23646df66c223c2379fe annotatedSource NCIT_C2571 @default.
- Be83d975d5d1c23646df66c223c2379fe annotatedTarget "An antimetabolite and a chlorine derivative of the intracellular secondary messenger, cyclic adenosine 3,5-monophosphate (cAMP), with potential antineoplastic activity. Tocladesine appears to be converted to 8-chloro-adenosine by phosphodiesterases and subsequently phosphorylated to 8-chloro-ATP, which functions as a purine analogue and competes with ATP in transcription. In addition, generation of 8-chloro-ATP depletes endogenous ATP pool that is essential for many biological reactions in intracellular energy transfer. As a result, this agent causes RNA synthesis inhibition, blocks cellular proliferation, and induces apoptosis." @default.