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- Be842eaa8c3d9e6196a7493f34ab03219 NCIT_P378 "NCI" @default.
- Be842eaa8c3d9e6196a7493f34ab03219 type Axiom @default.
- Be842eaa8c3d9e6196a7493f34ab03219 annotatedProperty IAO_0000115 @default.
- Be842eaa8c3d9e6196a7493f34ab03219 annotatedSource NCIT_C101525 @default.
- Be842eaa8c3d9e6196a7493f34ab03219 annotatedTarget "An inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6. The TRPV6 ion channel plays a key role in calcium homeostasis and is highly selective for calcium compared to other cations; it is overexpressed in a variety of tumors and initiates tumor cell growth, proliferation and metastases." @default.