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- Be85ecbe5906e0d36554761bda5ad50b6 NCIT_P378 "NCI" @default.
- Be85ecbe5906e0d36554761bda5ad50b6 type Axiom @default.
- Be85ecbe5906e0d36554761bda5ad50b6 annotatedProperty IAO_0000115 @default.
- Be85ecbe5906e0d36554761bda5ad50b6 annotatedSource NCIT_C77067 @default.
- Be85ecbe5906e0d36554761bda5ad50b6 annotatedTarget "A third generation, synthetic, water-soluble, pentapeptide analog of the marine depsipeptide dolastatin 15, with potential antimitotic and antineoplastic activities. Tasidotin and its metabolite, tasidotin C-carboxylate, suppress the dynamic instability behavior of the microtubules through a reduction of the shortening rate (disassembly); reduction of the switching frequency from growth to shortening; and by reducing microtubules growth time. This may eventually result in a reduction of cell growth." @default.