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- Be8d1d484c4c8b92398812728f38628da NCIT_P378 "NCI" @default.
- Be8d1d484c4c8b92398812728f38628da type Axiom @default.
- Be8d1d484c4c8b92398812728f38628da annotatedProperty IAO_0000115 @default.
- Be8d1d484c4c8b92398812728f38628da annotatedSource NCIT_C90781 @default.
- Be8d1d484c4c8b92398812728f38628da annotatedTarget "The sulfate salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia." @default.