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- Be8f450e23f66eee11ebdb265be14a9df NCIT_P378 "NCI" @default.
- Be8f450e23f66eee11ebdb265be14a9df type Axiom @default.
- Be8f450e23f66eee11ebdb265be14a9df annotatedProperty IAO_0000115 @default.
- Be8f450e23f66eee11ebdb265be14a9df annotatedSource NCIT_C28915 @default.
- Be8f450e23f66eee11ebdb265be14a9df annotatedTarget "The sodium salt form of cefoxitin, a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefoxitin sodium binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.