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- Be963f73aa3b7586f9f15c2875b6fb733 NCIT_P378 "NCI" @default.
- Be963f73aa3b7586f9f15c2875b6fb733 type Axiom @default.
- Be963f73aa3b7586f9f15c2875b6fb733 annotatedProperty IAO_0000115 @default.
- Be963f73aa3b7586f9f15c2875b6fb733 annotatedSource NCIT_C156732 @default.
- Be963f73aa3b7586f9f15c2875b6fb733 annotatedTarget "A recombinant, plasmid DNA expression vector encoding a 39 nucleotide (nt) short hairpin RNA (shRNA) specific for the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon intratumoral administration, the EGFR antisense DNA BB-401 is taken up by tumor cells and shRNA is transcribed. The shRNA is converted into small interfering RNA (siRNA) via the RNA interference (RNAi) pathway. The siRNA targets and binds to EGFR RNA expressed by tumor cells. This blocks EGFR mRNA translation and prevents EGFR protein expression." @default.