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- Bea8e0f4c794cd2f93d2f8ccdf2d63fb7 NCIT_P378 "NCI" @default.
- Bea8e0f4c794cd2f93d2f8ccdf2d63fb7 type Axiom @default.
- Bea8e0f4c794cd2f93d2f8ccdf2d63fb7 annotatedProperty IAO_0000115 @default.
- Bea8e0f4c794cd2f93d2f8ccdf2d63fb7 annotatedSource NCIT_C47619 @default.
- Bea8e0f4c794cd2f93d2f8ccdf2d63fb7 annotatedTarget "A pyridine derivative and a glucocorticoid synthesis inhibitor. Metyrapone inhibits 11-beta-hydroxylase, thereby inhibiting synthesis of cortisol from 11-deoxycortisol and corticosterone from desoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continuing stimulation of adrenal gland by ACTH results in accumulation of corticoid precursors, 11-desoxycortisol and desoxycorticosterone. These metabolites are excreted in urine that maybe used as indicators for pituitary responsiveness." @default.