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- Bea909b91de32438c5cb09230c5675ed6 hasDbXref "Orphanet:98909" @default.
- Bea909b91de32438c5cb09230c5675ed6 hasDbXref "https://orcid.org/0000-0001-5208-3432" @default.
- Bea909b91de32438c5cb09230c5675ed6 type Axiom @default.
- Bea909b91de32438c5cb09230c5675ed6 annotatedProperty IAO_0000115 @default.
- Bea909b91de32438c5cb09230c5675ed6 annotatedSource MONDO_0011076 @default.
- Bea909b91de32438c5cb09230c5675ed6 annotatedTarget "A rare genetic skeletal muscle disease characterized by abnormal chimeric aggregates of desmin and other cytoskeletal proteins and granulofilamentous material at the ultrastructural level in muscle biopsies and variable clinical/ myopathological features, age of disease onset and rate of disease progression. Patients present with bilateral skeletal muscle weakness that starts in distal leg muscles and spreads proximally, sometimes involving trunk, neck flexors and facial muscles and often cardiomyopathy manifested by conduction blocks, arrhythmias, chronic heart failure, and sometimes tachyarrhythmia. Weakness eventually leads to wheelchair dependence. Respiratory insufficiency can be a major cause of disability and death, beginning with nocturnal hyperventilation with oxygen desaturation and progressing to daytime respiratory failure." @default.