Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Beb1fdc898cadf17749040663c189d9e0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Beb1fdc898cadf17749040663c189d9e0 NCIT_P378 "NCI" @default.
- Beb1fdc898cadf17749040663c189d9e0 type Axiom @default.
- Beb1fdc898cadf17749040663c189d9e0 annotatedProperty IAO_0000115 @default.
- Beb1fdc898cadf17749040663c189d9e0 annotatedSource NCIT_C84880 @default.
- Beb1fdc898cadf17749040663c189d9e0 annotatedTarget "A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration and conversion from CEP-9722, CEP-8983 selectively binds to PARP 1 and 2, preventing repair of damaged DNA via base excision repair (BER). This agent enhances the accumulation of DNA strand breaks and promotes genomic instability and apoptosis. CEP-8983 may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand breaks in DNA." @default.