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- Beb223f1dcd7960fb096972c3d24006f9 NCIT_P378 "NCI" @default.
- Beb223f1dcd7960fb096972c3d24006f9 type Axiom @default.
- Beb223f1dcd7960fb096972c3d24006f9 annotatedProperty IAO_0000115 @default.
- Beb223f1dcd7960fb096972c3d24006f9 annotatedSource NCIT_C1390 @default.
- Beb223f1dcd7960fb096972c3d24006f9 annotatedTarget "A nonsedating derivative of thiobarbituric acid and a novel catalytic topoisomerase II inhibitor with antineoplastic activity. Merbarone interferes with DNA replication via binding directly to topoisomerase II at a domain that maybe shared by other topoisomerase II cleavage-enhancing agents, ex., etoposide. Its mechanism of action appears to be a novel one, since merbarone does not intercalate DNA nor stabilize DNA-topoisomerase II cleavable complexes." @default.