Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Beb48a1a62908034f55f2ff7f75a9a6d3> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Beb48a1a62908034f55f2ff7f75a9a6d3 NCIT_P378 "NCI" @default.
- Beb48a1a62908034f55f2ff7f75a9a6d3 type Axiom @default.
- Beb48a1a62908034f55f2ff7f75a9a6d3 annotatedProperty IAO_0000115 @default.
- Beb48a1a62908034f55f2ff7f75a9a6d3 annotatedSource NCIT_C106430 @default.
- Beb48a1a62908034f55f2ff7f75a9a6d3 annotatedTarget "A water soluble inhibitor of the protein phosphatase 2A (PP2A), with potential chemo- and radiotherapy enhancing activity. Upon injection, PP2A inhibitor LB-100 inhibits the removal of phosphate groups from proteins essential for cell cycle progression. When used with radio- or chemotherapy treatment, this agent prevents the activation of PP2A-mediated repair mechanisms and allows for malignant cells to progress through the cell cycle without having their damaged DNA repaired. This enhances the cytotoxic effect of the chemotherapeutic or radiotherapeutic agent and results in tumor cell apoptosis. PP2A, a serine/threonine phosphatase that plays a key role in the control of cell growth and DNA damage repair." @default.