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- Bec09f3d84ed1e026a922fbc0fa05ef61 NCIT_P378 "NCI" @default.
- Bec09f3d84ed1e026a922fbc0fa05ef61 type Axiom @default.
- Bec09f3d84ed1e026a922fbc0fa05ef61 annotatedProperty IAO_0000115 @default.
- Bec09f3d84ed1e026a922fbc0fa05ef61 annotatedSource NCIT_C97506 @default.
- Bec09f3d84ed1e026a922fbc0fa05ef61 annotatedTarget "A pegylated form of naloxone, a peripherally-acting mu-opioid receptor antagonist, that can be used to reduce opioid-induced symptoms. Upon administration, naloxegol binds to and blocks mu-opioid receptors in the peripheral nervous system. This prevents peripheral opioid receptor activation and abrogates opioid-induced side effects, such as opioid-induced constipation (OIC). Pegylation of naloxone reduces permeability across the blood-brain barrier (BBB) and prevents this agent from interfering with the analgesic activity of opioid receptor agonists." @default.