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- Bec1044ceac0dd68a654616d33cde9eab NCIT_P378 "NCI" @default.
- Bec1044ceac0dd68a654616d33cde9eab type Axiom @default.
- Bec1044ceac0dd68a654616d33cde9eab annotatedProperty IAO_0000115 @default.
- Bec1044ceac0dd68a654616d33cde9eab annotatedSource NCIT_C68921 @default.
- Bec1044ceac0dd68a654616d33cde9eab annotatedTarget "A 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hypervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity." @default.