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- Bec9a16b43da07d8b93ed285bfea57f05 NCIT_P378 "NCI" @default.
- Bec9a16b43da07d8b93ed285bfea57f05 type Axiom @default.
- Bec9a16b43da07d8b93ed285bfea57f05 annotatedProperty IAO_0000115 @default.
- Bec9a16b43da07d8b93ed285bfea57f05 annotatedSource NCIT_C103230 @default.
- Bec9a16b43da07d8b93ed285bfea57f05 annotatedTarget "A proprietary formulation consisting of a Phellodendron amurense (Amur cork tree) bark extract, often used in traditional Chinese medicine, with anti-inflammatory, anti-oxidant and potential chemopreventive and antineoplastic activities. Phellodendron amurense bark extract contains certain isoquinoline alkaloids, flavone glycosides and phenolic compounds. Upon administration of Phellodendron amurense bark extract, the various phytochemicals in this formulation modulate multiple signal transduction pathways. This agent appears to block the activation of the transcription factor cAMP response binding protein (CREB) and inhibits Akt signaling, thereby inhibiting tumor cell growth and inducing apoptosis in Akt- and CREB-overexpressing cancer cells. In addition, this agent inhibits cyclooxygenase type 2 (COX-2), nuclear factor kappa b (NF-kB) and tumor necrosis factor alpha (TNF-a)-mediated signaling; COX-2, NF-kB and TNF-a are upregulated in certain types of cancer and during inflammation." @default.